Trimetazidine Protects from Mercury-Induced Kidney Injury

<b><i>Introduction:</i></b> The presence of mercury in the environment is a worldwide concern. Inorganic present industrial materials, employed medical devices, widely used batteries, component fluorescent light bulbs, and it has been associated with human poisoning gold mining areas. nephrotoxicity induced by inorganic relevant health problem mainly developing countries. primary mechanism toxicity oxidative stress. Trimetazidine (TMZ) an anti-ischemic drug, which inhibits cellular stress, eliminates oxygen-free radicals, improves lipid metabolism. aim this study was to evaluate whether administration TMZ protects against mercuric chloride (HgCl<sub>2</sub>) kidney damage. <b><i>Methods:</i></b> Adult male Wistar rats received only HgCl<sub>2</sub> (4 mg/kg bw, sc) (Hg group, <i>n</i> = 5) or (3 ip) 30 min before (TMZHg 7). Simultaneously, control group (<i>n</i> 4) studied. After 4 days injection, urinary flow, urea creatinine (Cr) plasma levels, Cr clearance, glucose, sodium-dicarboxylate cotransporter 1 (NaDC1) urine were determined. Lipid peroxidation (MDA) glutathione (GSH) levels measured homogenates. <b><i>Results:</i></b> Rats treated showed increase fractional excretion water, glucosuria, NaDC1 as compared decrease clearance. TMZHg excretion, clearance when Hg group. Moreover, MDA GSH observed groups decreased increased, respectively, pretreatment. <b><i>Conclusion:</i></b> exerted renoprotective action HgCl<sub>2</sub>-induced renal injury, might be mediated reduction Considering absence TMZ, its clinical application damage due injury should considered. fact that commercially available simplify accelerate translation data “from bench bedside.” In context, become interesting new example drug repurposing.